LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder
نویسندگان
چکیده
منابع مشابه
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.
The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered promoter DNA methylation could play a critical role in mediating differential regulation of genes and in facilitating short-term adaptation in response to the environment. Her...
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In bipolar disorder (BD) and schizophrenia (SZ) rare and de novo chromosomal microdeletions and microduplications (CNVs) have strong effects on risk. For de novo CNVs, the risk of BD or SZ is 10% and for deletions of the q11 region on chromosome 22, the risk of either of these disorders is 77%. A not-insignificant minority of BD and SZ patients have these types of event (4-6.5%). Psychotherapeu...
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Background: Cognitive impairment is a common symptom in both Schizophrenia (SZ) and Bipolar Disorder (BD), and studies have demonstrated memory impairment in patients with these disorders. Objectives: To compare memory impairment in patients with SZ, BD with psychosis, and BD without psychosis. Materials & Methods: This study was a cross-sectional study conducted on 42 patients referred to Sh...
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CONTEXT The clinical and etiologic relation between autism spectrum disorders (ASDs) and schizophrenia is unclear. The degree to which these disorders share a basis in etiology has important implications for clinicians, researchers, and those affected by the disorders. OBJECTIVE To determine whether a family history of schizophrenia and/or bipolar disorder is a risk factor for ASD. DESIGN, ...
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The hypothesis that viruses or other infectious agents may cause schizophrenia or bipolar disorder dates to the 19th century but has recently been revived. It could explain many clinical, genetic, and epidemiologic aspects of these diseases, including the winter-spring birth seasonality, regional differences, urban birth, household crowding, having an older sibling, and prenatal exposure to inf...
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ژورنال
عنوان ژورنال: Human Genome Variation
سال: 2020
ISSN: 2054-345X
DOI: 10.1038/s41439-020-00117-7